Infection, Tumors and Autoimmunity – Report on the 11th Dresden Symposium on Autoantibodies held in Dresden on September 1-4, 2013

Conrad, K.; Chan, E.K.L.; Fritzler, M.J.; Humbel, R.L.; Meroni, P.L.; Steiner, G.; Shoenfeld, Y. (Eds.)
2013, 380 pages, eBook
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Volume 9 - 2013Contents

Chapter 1
Infections, Tumors and Autoimmunity

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA)
Carlo Perricone, Yehuda Shoenfeld

Possible role of infections in the pathogenesis of autoimmune liver diseases
Daniel S. Smyk and Dimitrios P. Bogdanos

GP2 – The link between innate and acquired immune system in the intestine
Dirk Roggenbuck, Dirk Reinhold, Dimitrios P. Bogdanos, Karsten Conrad

Vitamin D in infection and autoimmunity
E. Borella, Y. Shoenfeld

Clinical implications of anti-rods and rings autoantibodies in hepatitis C patients treated with interferon/ribavirin therapy
S. John Calise, Wendy C. Carcamo, and Edward K.L. Chan

The hyperferritinemic syndrome in infection and autoimmunity
Cristina Rosário, Yehuda Shoenfeld

The fate of the Ro autoantigen-associated Y RNAs in Coxsackievirus-infected cells Ger
J.M. Pruijn, Dirk den Braanker, Qian Feng, Frank J. van Kuppeveld

Autoantibodies to tumor-associated antigens (TAAs) as biomarkers in the immunodiagnosis of cancer
Liping Dai, Pengfei Ren, Xinxin Liu, Carlos A. Casiano, Jian-Ying Zhang

Immunoproteomic profiling of autoantibodies in prostate cancer: a health disparities perspective
Tino W. Sanchez, Anamika Basu, Saied Mirshahidi, Chen Chien-Shing, Susanne Montgomery, Colwick Wilson, Jianying Zhang, Nathan Wall and Carlos A. Casiano

Characterisation of novel autoantibody biomarkers in oncology and autoimmunity
Will Colón, Colin Wheeler, Ezam Uddin, Nicholas Workman, Pooja Agashe, Tim Vyse and Michael B. McAndrew

Chapter 2
Pathogenesis and Therapy of Autoimmune Diseases – Novel Aspects

The role of neutrophil extracellular traps (NETs) in autoimmunity and generation of autoantibodies
Elaine F. Kenny & Arturo Zychlinsky

Revisiting the cell death paradigm in systemic autoimmune diseases
Felipe Andrade

NETs and ANCA-associated vasculitides
Elena Csernok

Towards understanding the pathogenesis of granulomatosis with polyangiitis: The role of neutrophil extracellular traps
C. Lange, E. Csernok, J.U. Holle

Aggregation of NETs: flipping the switch to resolution of inflammation
Christine Schorn, Luis Munoz, Deborah Kienhöfer, Martin Herrmann, and Markus Hoffmann

Memory plasma cells in autoimmunity – An update
Falk Hiepe

Protective natural autoantibodies in atherogenesis and autoimmunity
Gregg J. Silverman and Caroline Grönwall

The interface between primary immunodeficiency and systemic lupus erythematosus
Sandro F. Perazzio, Magda Carneiro-Sampaio, Luis E.C. Andrade

Inherited defects in nucleic acid metabolism and autoimmunity
Stefanie Kretschmer, Nadja König, Min Ae Lee-Kirsch

Induction of autoimmunity by defects of intracellular nucleases: Mouse models for Aicardi-Goutières syndrome
Axel Roers

Anti-AT1R and anti-ETAR autoantibodies from patients with SSc and their agonistic effects
A. Kill, Christoph Tabeling, Anja A. Kühl, J. Günther, M.O. Becker, Harald Heidecke, D. Dragun, G.R. Burmester, G. Riemekasten

The use of Aptamers as a new tool for the treatment of autoantibody associated diseases
G. Wallukat, A. Haberland, S. Berg, E.J. Freyse, E. Salzsieder, W. Schulze, I. Schimke

Harnessing parasitic infection to treat autoimmunity
Miri Blank, Lachnish Jordan, Bashi Tomer and Yehuda Shoenfeld

Chapter 3
Immune Reactions against Drugs

Clinical relevance of anti-drug antibodies
Arno Kromminga

Mycophenolic acid and ribavirin induce cytoplasmic Rods and Rings (RR) structures in vivo, but only ribavirin induces anti-RR autoantibodies
Gerson D. Keppeke, Sandro F. Perazzio, Monica S. Prado, Edward K.L. Chan, Luis Eduardo C. Andrade

Effects of intracellular glutamine levels on the reversible assembly of cytoplasmic rod and ring autoantigenic structures
S. John Calise, Wendy C. Carcamo, Claire Krueger, Daniel L. Purich, and Edward K.L. Chan

Chapter 4
Autoantibodies in Systemic Autoimmune Rheumatic Diseases

4.1 Connective Tissue Diseases

Anti-Mup44 autoantibodies in inclusion-body myositis
Helma Pluk, Megan Herbert, Judith Stammen-Vogelzangs, Baziel G. van Engelen, Ger J.M. Pruijn

Autoantibody profiling in idiopathic inflammatory myopathies: Validation of the myositis antigens Mi-2a, MDA5, NXP2 and SAE1 in a line immune assay 
L. Komorowski, W. Meyer, T. Scheper, W. Schlumberger, A. Ott, P.J. Charles, C. Probst

Evaluation of recombinant TIF1-γ in a line immune assay for the detection of autoantibodies in idiopathic inflammatory myopathies
C. Probst, L. Komorowski, W. Meyer, T. Scheper, A. Ott, P.J. Charles, K. Danko, L. Bodoky, H. Chinoy, W. Schlumberger

Autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) a novel biomarker for statin associated necrotizing myopathies
Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Joe Philips, Lucile Musset, Michael Mahler

Autoantibody signatures of connective tissue disease patients identified with a bead-based assays approach
Angelika Lueking, Petra Budde, Heike Goehler, Jessica Schwermann, Martin Gamer, Klaus Marquardt, Anna Telaar, Daniel Chamrad, Carmen Theek, Matthias Schneider, Peter Schulz-Knappe

Identification of novel autoantibody signatures reflecting the heterogeneity in systemic lupus erythematosus
P. Budde, A. Lueking, S. Vordenbäumen, H. Göhler, M. Gamer, K. Marquardt, A. Telaar, D. Chamrad, C. Theek, B. Ostendorf, P. Schulz-Knappe, M. Schneider

What is the clinical significance of anti-Sm-antibodies in SLE patients? A comparison with anti-dsDNA-antibodies and C3
Alexandra Richartz, Thomas Rose, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Wolfgang Schlumberger, Gerd-Rüdiger Burmester, Karl Egerer, Robert Biesen and Falk Hiepe

Clinical evaluation of total and high avidity anti-dsDNA antibody EIA for the diagnosis of systemic lupus erythematosus
Pengjie Wan, Shuxia Zhou, Hua Cao, Weiping Li, Doug Scott, Joel Hardy, Tony Presitigiacomo, Jie Zheng

Significance of anti-C1q antibody detection in SLE patients with lupus nephritis 
Ivana Stiborová, Vlastimil Král, Stanislava Blažíčková 

4.2 Rheumatoid Arthritis

Autoantibodies in rheumatoid arthritis: predictors of disease, prognosticators of outcome and pathogenic players
Markus Hoffmann, Karin Lundberg and Günter Steiner

Antibodies against carbamylated proteins in different stages of rheumatoid arthritis
Leendert A. Trouw

Development and initial use of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides in rheumatoid arthritis patients 
Johan Rönnelid, Linda Mathsson, Mats Nystrand, Lars Klareskog, Monika Hansson

The anti-CCP2 is the anti-citrullinated protein antibody (ACPA) with highest diagnostic value in rheumatoid arthritis
E. Grenmyr and Y. Sommarin

Occurrence of anti-RA33 antibody in various types of juvenile idiopathic arthritis
Gabor Nagy, Barbara Szasz, Diana Garan, Ibolya Szollosi, Sandor Sipka, Tamas Constantin

MMP-3 is a marker for disease activity in rheumatoid arthritis
S. Reuter, T. Matthias

The conversion of QuantiFERON TB Gold test during biological treatment by anti-TNF preparations
E. Zanova, D. Kozakova, I. Rybar, I. Solovic, J. Rovensky

Interferon-gamma and QuantiFERON-TB Gold test conversion during biological treatment
D. Kozakova, E. Zanova, I. Rybar, I. Solovic, J. Rovensky

Chapter 5
Autoantibodies in Organ Specific Diseases

5.1 Neurological Diseases

New antibodies in multiple sclerosis
Bernhard Hemmer

Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis
Myrthe Rouwette, Jean-Paul Noben, Jack Van Horssen, Bart Van Wijmeersch, Raymond Hupperts, Peter J. Jongen, Marcel M. Verbeek, Peter P. De Deyn, Piet Stinissenand Veerle Somers

Diagnostic and pathophysiologic relevance of autoantibodies against aquaporin-4
F. Paul, B. Wildemann, S. Jarius

Autoantibodies against the neuronal surface antigen DPPX: markers for an emerging neurological disease entity
Bettina Balint, Simon Nagel, Uwe Haberkorn, Christian Probst, Inga-Madeleine Blöcker, Bianca Teegen, Kristin Rentzsch, Ramona Bahtz, Lars Komorowski, Sandra Saschenbrecker, Andreas Kastrup, Martin Kuthe, Hans-Michael Meinck, Winfried Stöcker

Nonradioactive determination of autoantibodies against acetylcholine receptors in myasthenia gravis: A new enzyme-linked immunoassay for manual and automated processing
J. Westermann, E. Denczyk, C. Probst, L. Komorowski, W. Schlumberger

Generation of stable HEp-2 cell line M4 expressing human muscle-specific kinase for automatic videoscan-based immunofluorescence diagnostics of Myasthenia gravis
S. George, S. Paulick, I. Knütter, N. Röber, R. Hiemann, D. Roggenbuck, K. Conrad and J.-H. Küpper

Clinical validation of a novel immunofluorescence assay for the detection of anti-MuSK antibodies based on MuSK transfected HEp-2 cells
Nadja Röber, Silke Weber, Jochen Schäfer, Sandra George, Ilka Knütter, Dirk Roggenbuck, Jan-Heiner Küpper, Karsten Conrad

Pleural mesothelioma and anti-MA2-associated encephalitis
Adriano Jiménez-Escrig, Silvia Medina, Ángela Carrasco

What should be the cut-off for VGKC complex antibodies?
Sylvie Coito, Réné-Louis Humbel

Multi-center validation study of DNER as the target of anti-PCA-Tr autoantibodies associated with paraneoplastic neurological syndrome
Kristin Rentzsch, Inga-Madeleine Blöcker, Bianca Teegen, Winfried Stöcker, Francesc Graus, Véronique Rogemond, Jérome Hônnorat, Esther S.P. Hulsenboom, Peter A.E. Sillevis Smitt, Christian Probst, Lars Komorowski

Multi-parametric recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies associated with paraneoplastic neurological syndromes
Inga-Madeleine Blöcker, Christiane Radzimski, Mandy Unger, Linda Döring, Winfried Stöcker, Josep Dalmau, Peter Sillevis Smitt, Lars Komorowski, Christian Probst

5.2 Liver and Gastrointestinal Diseases

Preliminary report: Detection of antibodies against D-3-phosphoglycerate dehydrogenase (PGDH) in autoimmune liver diseases using a line immune assay
W. Meyer, C. Probst, L. Komorowski, A. Ott, T. Scheper, W. Schlumberger, W. Stöcker and H. Yan

Can the HEp-2 cell assay replace the indirect immunofluorescence on rat cryostat section for AMA-M2 screening?
Kristin Kühnert, Uta Kießling, Teresa Trimpop, Manuela Rejzek, Andrea Thieme, Nadja Röber, Karsten Conrad

Prevalence of anti-nuclear antibodies in patients with primary biliary cirrhosis
Ana Kozmar, Ivan Padjen, Miroslav Mayer, Mirna Sentic, Branko Malenica

Evaluation of a high sensitive assay for the diagnosis of celiac disease
Lisbeth Witt, Martin Salden, Klas Sjöberg, Fritz Koning and Yngve Sommarin

CytoBead-assay for the simultaneous detection of celiac disease specific antibodies and IgA deficiency
Nadja Röber, Kai Grossmann, Ilka Knütter, Rico Hiemann, Mandy Sowa, Martin W. Laass, Karsten Conrad, Dirk Roggenbuck

Pancreatic-specific autoantibodies to glycoprotein 2 in pediatric celiac disease
Martin W. Laass, Dirk Roggenbuck, Ursula Range, Nadja Röber, Karsten Conrad

Comparison of two ELISAs for the detection of anti-MZGP2 antibodies as a new serological marker for Crohn`s disease
Laura M. Stinton, Gary L. Norman, Zakera Shums, Maria T. Arias-Loste, Marcos Lopez-Hoyos, Michael Mahler

5.3 Endocrine, Kidney and Skin Diseases

Detection of autoimmunity against the insulin-and insulin-like growth factor-1 receptor and their prevalence in humans
T. Welsink, C. Schwiebert, W.B. Minich, L. Schomburg

Role of autoantibodies anti zinc transporter protein (anti-ZnT8) in the diagnosis and follow-up of type I diabetes mellitus: an Italian experience
S. Zago, M. Fabris, P. Melli, M. Zanatta, T. Basso, A. Comici, E. Carlin, G. Zanette, E. Tonutti, A. Rosolen A. Radice

Serological profile of idiopathic membranous nephropathy cohort
Astrid Behnert, Beina Teng, Janina Müller-Deile, Andrej Skoberne, Mario Schiffer, Marvin J. Fritzler

Our experience with anti-phospholipase A2 receptor (PLA2R) indirect immunofluorescence test
I. Janatková, M. Hinďoš, Z. Hrušková, B. Svobodová, V. Tesař, K. Malíčková, T. Zima 

Evaluation of a new ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy
W. Schlumberger, C. Dähnrich, C. Probst, B. Seitz-Polski, V. Esnault, J.F. Wetzels, J.M. Hofstra, E. Hoxha, R.A. Stahl, G. Lambeau, W. Stöcker, L. Komorowski

Detection of anti-phospholipase A2 receptor autoantibodies: A comparison of three different immunoassays
Astrid Behnert , Mario Schiffer, Michael Mahler, Marvin J. Fritzler

Anti-M-type Phospholipase A2 Receptor (PLA2r) antibodies in diagnosis and follow-up of idiopathic membranous nephropathy (IMN)
S. Glionna, L. Bianchi, B. Trezzi, M. D’Amico, T. Stellato, D. Santoro, R.A. Sinico and A. Radice 

The antiphospolipid antibodies in psoriasis patients with metabolic syndrome and non-alcoholic fatty liver disease comorbidities
N. Virstyuk, M. Volochynovych, M. Nykyforuk

Development of sensitive and specific assays for serological diagnosis of anti-laminin 332 mucous membrane pemphigoid
S. Groth, A. Abadpour, K. Vafia, C. Probst, L. Komorowski, W. Schlumberger, W. Stöcker, D. Zillikens and E. Schmidt

Autoantibodies to Golgi complex and Ro51 protein in non-specific interstitial pneumonia (NSIP): case report and literature review
S. Andrejevic, B. Milenkovic, J. Stojsic, R. Stevic, B. Bonaci-Nikolic

Chapter 6
Methodical Aspects and Diagnostic Strategies

6.1 New Concepts and Novel Assays

New Concepts and Approaches to Autoantibody Testing
Laura M. Sinton, Marvin J. Fritzler

PR3-ANCA as a promising biomarker for the diagnosis of primary sclerosing cholangitis (PSC)
Laura M. Stinton, Chelsea Bentow, Michael Mahler, Gary L. Norman, Bertus Eksteen, Andrew L. Mason, Gilaad G. Kaplan, Bjorn Lindkvist, Angela Cheung, Harry Janssen, Marvin J. Fritzler

Standardization of reference material for autoantibody testing: the state of the art
Pier Luigi Meroni, Maria Orietta Borghi

New diagnostics in autoimmunity: a review and our experience
Boris Gilburd, Carlo Perricone, Enrica Cipriano, Nancy Agmon-Levin, Yehuda Shoenfeld

Evaluation of a novel sensitive and reliable Lateral Flow Assay (LFA) for the detection of anti-dsDNA antibodies Anti-dsDNA LFA
N. Offermann, M. Petschinka and M. Fooke

Microtiter plate-based multiparametric assay for detection of non-organ specific autoantibodies
Jana Langer, Erik Höchel, Klemens Löster, Martin Eberhardt, Nadja Röber, Karsten Conrad, Silvia Porstmann, Tomas Porstmann

CytoBead ANCA -a novel indirect immunofluorescence test for the simultaneous detection of anti-neutrophil cytoplasmic antibodies
Mandy Sowa, Ilka Knütter, Rico Hiemann, Kai Grossmann, Nadja Röber, Ursula Anderer, Karsten Conrad, Dirk Reinhold, Elena Csernok, Dirk Roggenbuck

Evaluation of ANCA by automated IFA image analysis on NOVA View
Carol E. Buchner, Cassandra C. Bryant, Rachel A. Rosenblum, Marlene Gonzalez, Gabriella Lakos

Development of a method for multiplex real-time analysis of enzymatic activity on a microbead-chip
Stefan Rödiger, Alexander Böhm, Jörg Nitschke, Luba Stavitskaya, Melanie Gruner, Alena V. Kundzer, Margarita V. Volkova, I. Generalov, Carsten Schmidt, Christian Schröder, Dirk Roggenbuck, Peter Schierack

6.2 Antinuclear Antibodies – Diagnostic Strategies and Novel Developments

CytoBead – A novel platform for antibody multiplex analyses
Rico Hiemann, Mandy Sowa, Kai Grossmann, Ilka Knütter, Juliane Scholz, Nadja Röber, Ursula Anderer, Dirk Reinhold, Peter Schierack, Karsten Conrad, Dirk Roggenbuck

Anti-nuclear antibodies: a long way to harmonization
Jan Damoiseaux, Nancy Agmon-Levin

Standardization of ANA-HEp-2 immunofluorescence pattern nomenclature
Wilson M. Cruvinel, Paulo L.C. Francescantonio, Alessandra Dellavance, Luis E.C. Andrade

ANA measurement by IIF in comparison to other methods in the diagnosis of connective tissue diseases
Xavier Bossuyt

Reading and interpretation of ANA immunofluorescence tests: results of a comparative study with six automated systems
Nicola Bizzaro, Stefan Platzgummer, Elio Tonutti, Antonio Antico, Danila Bassetti, Danilo Villalta, Fiorenza Pesente, Francesco Cucchiaro, Marilina Tampoia, Renato Tozzoli

Efficient autoantibody titration using indirect immunofluorescence assays (IIFA)
Jan Martinek, Ivo Lochman, Alexandra Lochmanová, Vladimír Krauz 

Autoimmunity diagnostic strategies (ANA, anti-dsDNA, anti-ENA) in Italian clinical laboratories
A. Radice, L. Bianchi, S. Glionna, B. Trezzi

Evaluation of ANA testing results: is there a need for revision of our protocol for antibody specificity testing?
Andrea Tesija Kuna, Ines Vukasovic, Nada Vrkic

Automation in ANA HEp-2 cells microscopy: can the machine substitute the human eye? 
Cristovao Pitangueira Mangueira, Eliane Aparecida Rosseto

HELIOS, a bright future for ANA -automated indirect immunofluorescence (IIF) assay
B. Gilburd, N. Agmon-Levin, T. Martins, A. Petzold, T. Matthias and Y. Shoenfeld

Comparability of the AESKUSLIDES ANA-HEp-2 antinuclear antibody (ANA) immunological test system with a commercially available system
Torsten Matthias, Sascha Pfeiffer, Trishna Martins, Peter Trinder and Andrea Petzold

92CytoBead ANA -a novel indirect immunofluorescence test for the simultaneous detection of anti-nuclear antibodies
Juliane Scholz, Ilka Knütter, Kai Grossmann, Rico Hiemann, Mandy Sowa, Nadja Röber, Karsten Conrad, Peter Schierack, Dirk Roggenbuck

Evaluation of a novel chemiluminescent assay (QUANTA Flash® CTD Screen Plus) for the rapid detection of autoantibodies in systemic autoimmune rheumatic diseases
C. Bentow, A. Seaman, A. Swart, A. Shikhman, N. Goodman, M. Mahler

Quantitative results of automated indirect immunofluorescence enable value added reporting for antinuclear antibody testing
Sofie Schouwers, Myriam Bonnet, Patrick Verschueren, René Westhovens, Daniel Blockmans, Godelieve Mariën, Xavier Bossuyt

Optimization of the automated HEp-2 cell assay by stepwise improvement of software algorithms
Rico Hiemann, Nadja Röber, Dirk Roggenbuck, Karsten Conrad

Autoantibodies to mitotic cells
René-Louis Humbel

Anti-nematin antibodies in practice
J. Goetz, R.L. Humbel, G. Uettwiller, F. Habersetzer, M. Doffoel

The clinical significance of anti-DFS70 antibodies as part of ANA testing
Michael Mahler

Prevalence and clinical associations of anti-DFS70 antibodies in samples with high titer of ANA but without detectable fine-specificity
Michael Mahler, Sofie Schouwers, Roger Albesa, Eric Tena, Nathalie Vandeputte, Doreen Dillaerts, X. Bossuyt

LEDGF/DFS70 antibodies and DFS pattern in routine diagnostics
Uwe Höpner, Tim Fülling, Uta Kießling, Teresa Trimpop, Manuela Rejzek, Andrea Thieme, Nadja Röber, Karsten Conrad

Longitudinal study of anti-DFS70 antibodies in 5 patients without antinuclear antibody associated autoimmune rheumatic disease
Sofie Schouwers, Michael Mahler, Doreen Dilaerts, Nathalie Vandeputte, Xavier Bossuyt

Evaluation of the first dot blot assay for the detection of anti DFS 70 antibodies as part of a 12plex ANA Profile
Johannes Schulte-Pelkum, Eric Tena, Alain Vigneron, Nicolas Bodart, Michael Mahler

Novel autoantibodies showing chromatin binding in the HEp-2 cell assay
Angelika Lueking, Heike Goehler, Petra Rengers, Martin Gamer, Klaus Marquardt, Petra Budde, Anna Telaar, Daniel Chamrad, Carmen Theek, Karsten Conrad, and Peter Schulz-Knappe

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