1. Evidence shows that maintaining mean arterial blood pressures in the range of 70-80 mmHg and increasing hypotension durations below the recommended range can increase mortality and endorgan dysfunction postoperatively.
2. Maintaining perfusion and oxygenation, especially to the brain and the kidneys, during CPB requires an understanding of capillary perfusion. Adequate oxygenation is typically assessed using a combination of pulse oximetry, cerebral oximetry, and arterial blood oxygen pressure. Hypotension during CPB has many potential causes, and evaluation and treatment need to be a joint process involving the surgeon, anesthesist, and perfusionist. Vasoplegia while on CPB is due to interaction between the patient´s blood and the CPB circuit and can be difficult to treat.
3. Many different vasopressors can improve perfusion pressure while on CPB, with different mechanisms of action, indications, and physiologic effects. Epinephrine and norepinephrine are the most commonly used, and function to increase systemic vascular resistance significantly.
4. Anesthesia while on CPB may be maintained with inhalation or intravenous agents, both of which have advantages and disadvantages. No outcome differences could be demonstrated between those techniques.
5. Malignant hyperthermia is an anesthetic emergency that may present while on CPB and requires expertise to diagnose and treat.
6. Anticoagulation while on CPB is typically maintained with heparin, though resistance may occur and can be treated with fresh frozen plasma or antithrombin III. Heparin is reversed with protamine sulfate, which has its own risks and potential side effects.
7. Anemia and coagulopathy are a constant concern during cardiac surgery, especially for patients on CPB, due to the loss of normal coagulation from interactions between platelets and the CPB circuit. Treating this conditions is necessary to decrease complications, but administration of non-autologous blood products can lead to transfusion reactions and other complications.
8. While most normal metabolic functions are maintained on CPB, non-pulsatile bloodflow, as well as periods of hypotension and hypoxia, can lead to metabolic derangements that may require artificial correction by the perfusionist or the anesthesist via renal replacement therapy.
9. Air embolism is a potentially catastrophic complication of CPB, and the anesthesist, the perfusionist and the surgeon must all be vigilant to diagnose and treat this event.
10. Transesophageal echocardiography, an excellent modality used to diagnose, monitor, and direct therapy towards the patient undergoing cardiac surgery, plays a large role in patient management.
The textbook ´Extracorporeal Circulation in Theory and Practice´ serves as comprehensive review for perfusionists, anesthesiologists, pulmonoligsts, surgeons, ICU-nurses and ECMO-specialists.