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Surfactant replacement therapy in experimental and clinical studies
Serge J. C. Verbrugge & Burkhard Lachmann


Since 1980, more than 100,000 premature infants suffering from respiratory distress syndrome (RDS) due to a surfactant deficiency have been successfully treated with exogenous surfactant almost without any side-effects [1,2]. Biochemical and biophysical abnormalities of the pulmonary surfactant system are also seen in other diseases such as the adult respiratory distress syndrome (ARDS) [3,4], infectious lung disease [5] and after cardiopulmonary bypass surgery [6]. This paper focusses on the advances in surfactant replacement therapy in experimental and clinical studies.

Keywords: animal, ARDS, clinical, surfactant

Applied Cardiopulmonary Pathophysiology 7: 237-250, 1998

Prof. Dr. Dr. Burkhard Lachmann
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Erasmus University Rotterdam
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