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| Hemodynamics and
catecholamines in anesthesia with different
concentrations of xenon Thomas Marx, Doris Wagner, Stefan Baeder, Axel Goertz, Michael Georgieff & Gebhard Froeba Background: During xenon anesthesia with inspiratory concentrations of 1 MAC, no adverse effects on cardiovascular stability were reported until present. During different surgical procedures, small and not significant increases in plasma norepinephrine and not significant decreases in plasma epinephrine concentrations were observed. Plasma dopamine concentrations remained unaltered. Excluding the influence of different surgical stimuli and to investigate the influence of different concentrations of xenon, we conducted a study in an experimental animal model during standardized surgical stimulation. Methods: Twenty-eight pigs were randomly assigned to one of four groups: Total intravenous anesthesia (TIVA) as control group, xenon anesthesia with concentrations of 30%, 50% or 70%. Open dissection of femoral artery was used as surgical stimulus. Hemodynamic parameters were measured on-line by arterial and Swan Ganz catheter. The depth of anesthesia was monitored using the spectral edge frequency SEF 95. Plasma concentrations of dopamine, norepinephrine and epinephrine were measured by High-Performance-Liquid-Chromatography (HPLC). Results: All hemodynamic parameters were not significantly changed during xenon anesthesia. Plasma dopamine and norepinephrine concentrations remained within normal limits. Compared to controls, epinephrine concentrations were significantly reduced in all xenon groups. Conclusions: Xenon anesthesia with inspiratory concentrations between 30% and 70% is associated with a high degree of cardiovascular stability. Significant reduction of epinephrine levels seems to be a specific xenon effect, occurring even in subanesthetic concentrations of 30% and 50%. Keywords: Anesthesia inhalation, catecholamines, hemodynamics, xenon Applied Cardiopulmonary Pathophysiology 7: 215-221, 1998 Thomas Marx, M.D. |
| PABST SCIENCE PUBLISHERS Lengerich, Berlin, Düsseldorf, Leipzig, Riga, Scottsdale AZ (USA), Wien, Zagreb |
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