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| Xenon washin and washout
time during controlled mechanically ventilation in an
animal model Gebhard Froeba, Stefan Baeder, Enrico Calzia, Michael Georgieff & Thomas Marx Xenon is known to be a potent anaesthetic agent (MAC 71%). With a blood/gas solubility coefficient of 0.14 fast washin and washout has to be expected. Goal of the study was to investigate the influence of different xenon concentrations on the washin and washout time under constant conditions of ventilation and haemodynamics. After approval by the local animal commission 21 pigs were assigned into 3 groups: anaesthesia with inspiratory concentration of 30%, 50% or 70% xenon in oxygen. The inspiratory or expiratory xenon concentrations were measured by mass spectrometry. Ratios FA/FI of 0.95 were reached after 112 sec in the 70% group, 164 sec in the 50% and 284 sec in the 30% group. An elimination value FA/FAo below 0.15 was obtained at 398 sec (Xenon 70%), 432 sec (Xenon 50%) and 452 sec (Xenon 30%). Xenon represents one of the fastest inhaled anaesthetic agents. Keywords: Xenon, washin, washout Applied Cardiopulmonary Pathophysiology 7: 157-160, 1998 Gebhard Froeba, M.D. |
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