K. Conrad, E. K. L. Chan, M. J. Fritzler, R.L. Humbel,
P. von Landenberg, Y. Shoenfeld (Eds.)
From Pathogenesis to Therapy of Autoimmune Diseases
Chapter 1: The Spectrum and Pathogenesis of
Noninfectious Inflammatory and Sclerosing Diseases
T. Kamisawa, K. Tsuruta, T. Sasaki: IgG4-related sclerosing disease
M. F. McDermott and D. McGonagle: The autoinflammatory-autoimmune
continuum
Chapter 2: The Role of Epigenetics and Innate Immunity in the
Pathogenesis of Autoimmune Diseases
O. Sánchez-Pernaute, J. Stanczyk, F. I. Romero-Bueno, S. Gay: MicroRNA in
the pathogenesis of systemic lupus: current status and future perspectives
P. von Landenberg: Toll like receptors and autoimmunity
E. Csernok: Proteinase 3 and its receptors: linking innate immunity to
autoimmunity in ANCA-associated vasculitides
C. Chizzolini and P. L.Meroni: Agonistic autoantibodies targeting innate
immunity receptors:The example of TLR4 in systemic sclerosis
C. M. Hedrich, J. H. Bream: Epigenetic regulation of IL-10 expression:
Activation dependent changes in DNA methylation patterns of CD4+ T cell
subsets 59
Chapter 3: Novel and Esoteric Autoantibodies
M. J. Fritzler: The clinical paradox of esoteric and novel autoantibodies
A. Kowald, G. Bartsch, H. Klocker,M. Schneider, P. Amersdorfer, S. Müllner,
A. Lueking: The UNIarray® technology platform for development of novel
autoantibody biomarkers in IVD applications
J.Y. F. Chan,H.Yoshida, A.Mizutani,Y.Yamasaki,Y. Li,M. R. Bubb, E. S.
Sobel, E. K. L. Chan, W. H. Reeves,M. Satoh: Autoantibodies to RNA
helicase A as a new serological marker of early SLE
M. Blüthner, H. Appelhans, I. Moosbrugger, C.Wiemann, D. Lenz, H. P.
Seelig: Identification of inosine-1,2-monophosphate-dehydrogenase-2 as a
novel autoantigen
M. Blüthner, H. Appelhans, I. Moosbrugger, C.Wiemann, J. Ludwig, H. P.
Seelig: Identification of Rho-GTPase-activating protein p26 as a novel
autoantigen
A. Swart, M. Mahler,M. J. Fritzler: The cell cycle protein Nop52 is a
candidate target autoantigen
K. Op De Beéck, K. Van den Bergh, L. Maes, G. Michiels, P. Verschueren,
R.Westhovens, D. Blockmans, X. Bossuyt: Heterogeneous nuclear
ribonucleoproteins, novel target antigens of autoantibodies in autoimmune
disease?
K. Somers, R. Hupperts, C. Zwanikken, P. Stinissen and V. Somers:
Sperm-associated antigen 16 isoform 2: a novel candidate autoantigen in
multiple sclerosis
B. Preuß, J. Dengjel, S. Stevanovic, R. Klein: Identification of the β-
and γ-subunits of F1-ATPase as target antigens in anti-M2/PDC-E2 negative
primary biliary cirrhosis (PBC) 118
B. Preuß, C. Berg, F. Altenberend,M. Gregor, S. Stevanovic, R. Klein: New
autoantibodies in primary sclerosing cholangitis: reactivity with distinct
immunodominant epitopes of sulfite oxidase
J. Vencovský, H. Mann, I. Putová, Z. Betteridge, H. Gunawardena, N.McHugh:
Anti-p155/140 (anti-TIF1γ) autoantibodies in patients with cancer
associated myositis detected in a single centre 122
Chapter 4: Biology of Autoantigen/Autoantibody Systems
W.C. Carcamo, B. Yao, M. Satoh,W.H. Reeves, C. Liu, G. Covini, C.A. von
Mühlen, E. K. L. Chan: Cytoplasmic rings/rods as autoimmune targets of
emerging human autoantibodies associated with HCV virus infection and
interferon therapy
L. S. Leoh,M.Mediavilla-Varela, A. Basu, C. A. Casiano: Autoantibodies to
LEDGFp75/DFS70: natural autoantibodies or sensors of an augmented state of
cellular oxidative stress?
E. Feist: Circulating proteasomes and autoantibodies
Chapter 5: Methodical Aspects and Diagnostic Strategies
X. Bossuyt: Clinical performance characteristics of a laboratory test
P. L. Meroni: Recommendations of the ACR committee on the standardization
of autoantibody detection
A. De Nicolo,M. Tampoia et al:.Laboratory policies on the management of
autoimmune diseases in a cohort of Italian laboratories
K.-P.Wandinger, C. Probst, L. Komorowski, S. Saschenbrecker, A. Rosemann,
T. Mothes, D. Zillikens, J. Dalmau, S. Jarius, W. Schlumberger,W. Stöcker:
Novel recombinant antigenic targets for the determination of (auto)antibodies
in autoimmune dermatoses, neurological disorders and gastrointestinal
diseases
P. Lorenz, Z. Qian, M. Hecker, M. Kreutzer, F. Steinbeck, Y. Li, M.O.
Glocker, H.-J. Thiesen: Stratification of autoantibody signatures in human
sera by peptide epitope profiling
M. Mahler and M. Fritzler: Peptide resolved diagnostics in systemic
autoimmune diseases: Potentials and pitfalls
R. Hiemann, D. Roggenbuck, U. Sack, K. Conrad: Detection and
differentiation of non-organ specific autoantibodies by a fully automated
HEp-2 cell assay
K. Großmann, U. Schedler, I. Berger, U. Sack, K. Conrad: Technical
solutions and advances for microbead-based immunoassays
K. Großmann, A. Böhm, J. Nitschke, R. Hiemann, P. Schierack, C. Schröder,
K. Conrad, U. Sack: Comparison of light sources for measurement of single
and multiplex bead assays
S. Signorini, L. Lattuada, R. Colombo: BioPlex™2200 multiplex ANAscreen
assay: a novel approach for the detection of antinuclear autoantibodies
Chapter 6: Pathogenetic Aspects and Serological Diagnostics of Systemic
Autoimmune Diseases
6.1 Rheumatoid Arthritis
J. J. B. C. van Beers,W. J. van Venrooij, G. J. M. Pruijn: Two major
classes of rheumatoid arthritis: CCP distinguishes between ACPA-positive
and ACPA-negative RA
G. Steiner, M. Hoffmann: Pathogenic and clinical relevance of rheumatoid
arthritis associated autoantibodies
K. Somers, P. Geusens, P. Stinissen, V. Somers: Novel autoantibody targets
in seronegative rheumatoid arthritis
M. Lora, J. Rotman, H. A.M´enard, D. Kast, C. Daehnrich,W. Stöcker,W.
Schlumberger: Comparison of the research-based anti-Sa with the EUROIMMUN
commercial anti-Sa ELISA to monitor rheumatoid arthritis activity
A. Lueking, A. Kowald,M. Schneider, H. E. Meyer, J. Beator, S.Müllner:
Development of novel antibody biomarkers for diagnostic protein biochips –
the rheumatoid arthritis case study
O. Abade, I. Abreu, F. Pimentel, M. Parente, J. Vaz Patto, R. Figueiredo,
D. Ligeiro, C. Miguel, A. Teixeira, H. Trindade: Autoantibody production
in early undifferentiated arthritis 319
C. Lingenfelter, S.Merrill, C. Nuun, D. Atkinson, X. Guo,W. Kumfert, T.
Prestigiacomo: Diagnostic sensitivity and specificity for rheumatoid
arthritis by the Bio-Rad Kallestad ANTI-CCP II assay
6.2: Systemic Lupus Erythematosus
L. E. Munoz, C. Schulze, C. Janko, C. Schorn, K. Sarter, M. Herrmann: The
mosaic of the etiopathogenesis of SLE – Role of chromatin binding
autoantibodies
F. Stephan, R. Manoe, B. Zwart, I. Bulder, L. Aarden, S. Zeerleder:
Decreased nucleosome releasing factor activity in patients with systemic
lupus erythematosus
B. Schlüter, G. Bonsmann, M. Gaubitz, P.Willeke: Effect of antigen
affinity and isotype specificity on the diagnostic efficiency of
anti-dsDNA autoantibody tests in systemic lupus erythematosus patients
R. Tripmacher, C. Kuznia, D. Roggenbuck, T. Büttner, B. Radau, K. Conrad,
V. Jansen, A. Schilke, A. Köster, S.Tobisch, B. Spott, R. Lange: Current
status of anti-dsDNA antibody diagnostics in the hospital Laborverbund
M. Mahler, M. van Liempt, J. Schulte-Pelkum, S. Schneider, T. Alexander,
A. Kromminga, M. Fooke, F. Hiepe: Evaluation of a novel dsDNA ELISA for
SLE disease activity measurement
Y. Thabet, A. Achour, A. Mankai,W. Sakly, Y. Renaudineau, P. Youinou, I.
Ghedira: Anti-α actinin antibodies in systemic lupus erythematosus
M. A. Lee-Kirsch, D. Chowdhury, S. Harvey, M. Gong, L. Senenko, K. Engel,
M. Gahr, J. Lieberman, F.W. Perrino, N. Hubner: A mutation in TREX1 that
impairs susceptibility to granzyme A-mediated cell death causes familial
chilblain lupus
L. Ostanek, D. Bobrowska-Snarska, M. Ostanek, A. Binczak-Kuleta, A.
Ciechanowicz, M. Brzosko: VEGF gene polymorphisms in patients with
systemic Lupus erythematosus
J. C. Möller, G. Hahn, F. Pessler: Corticosteroid-induced spinal epidural
lipomatosis in the pediatric patients with chronic autoimmune disorders
6.3: Anti-Phospholipid Syndrome and Systemic Vasculitides
S. D’Ippolito, R.Marana, R. Castellani, C. Tersigni, A. Caruso, N. Di
Simone: Antiphospholipid antibodies affect the process of angiogenesis:
novel mechanism of placental damage
T. Colasanti, P.Margutti, P.Matarrese, F. Delunardo, B. Ascione, D.
Vacirca,W. Malorni, E. Ortona: Gender differences in oxidative stress and
apoptosis of vascular cells induced by autoantibodies specific to RLIP76
A. Ceribelli, I. Cavazzana,A.Tincani, F. Franceschini, B. A. Pauley, J.Y.
F. Chan, E. K. L. Chan, M. Satoh: Anti-Argonaute2 (Ago2/Su) and -Ro
antibodies are the common autoantibody specificities in primary
anti-phospholipid syndrome (PAPS)
N. Virstyuk, V. Neyko, E. Cherkachuna, O. Virstyuk: The antiphospholipid
antibodies in patients with chronic heart failure
O. Virstyuk, R. D. Gerasymchuk, N. Virstyuk, R. Portyuk: The
antiphospholipid syndrome in acute ischemic stroke patients with insulin
resistance
M.W. Hayman, C. Slade, K. Chamberlain, N. Cook,M. B. Spellerberg, J. L.
O’Donnell: Performance evaluation of PR3-ANCA ELISAs
C. Defendenti, M. F. Spina, M. Longo, S. Bollani, A. Cereda, S. Saibeni,
A. Reina, G. Guercilena, S. Bruno, M. Saudelli, F. Atzeni, P.
Sarzi-Puttini: Autoimmunity in patientswith anti-neutrophil cytoplasmic
antibodies:retrospective analysis of an Italian cohort of ANCA positive
patients
L. Cebecauer, V. Král, J. Lupac, I. Lochman: ANCA or other neutrophil
specific antibodies (NSA)
Y. Ben Haj Hmida, D. Bouzid, S. Boukthir,M. Ben Ayed, H.Masmoudi: Clinical
relevance of ANCA in routine care
A. Radice, L. Bianchi, A. Palumbo, R. A. Sinico: A novel PR3-ANCA ELISA
with a mixture of human purified and recombinant PR3 as solid-phase
antigen
D. Roggenbuck, T. Büttner, L. Hoffmann, H. Schmechta, D. Reinhold, K.
Conrad: High sensitive detection of autoantibodies to proteinase 3 (PR3)
by a novel anchor ELISA
I. Knütter, T. Büttner, J. Scholka, D. Roggenbuck, U. Anderer: A novel
immunofluorescence assay for the Differentiation of pANCA and ANA
6.4: Systemic Sclerosis
K. Hanke, C. S. Brückner,M. Becker,W. Meyer,W. Schlumberger, G.
Riemekasten: Anti-CENP-A and anti-CENP-B antibodies show high concordance
and similar clinical associations in patients with systemic sclerosis
despite completely different underlying protein sequences
L. Maes, K. Op De Be´eck, K.Van den Bergh, P.Verschueren, R.Westhovens, D.
Blockmans, M. Mahler, X. Bossuyt: Evaluation of the in-house developed dot
blot method and ELISA for the detection of anti-PM/Scl100 autoantibodies
in systemic autoimmune diseases
M. Mahler,M. Siegemund,W.Meyer,M. Petschinka, M. J. Fritzler: Anti-PM/Scl-antibodies
in systemic sclerosis: Comparison between PM1-Alpha ELISA and a line assay
with recombinant PM/Scl-75c and PM/Scl-100
S. Costa, M. Mondini, V. Caneparo, Italian FIRMA Group, S. Landolfo,M.
Gariglio: Anti-IFI16 autoantibodies: a new marker in autoimmunity
A. Ceribelli, I. Cavazzana, P. Airo, A. Tincani, F. Franceschini, B. A.
Pauley, E. K. L. Chan, M. Satoh: Anti-Th/To antibodies in Italian
scleroderma patients: clinical and immunological correlations and
comparison with patients with anti-centromere (ACA) antibodies
Chapter 7: Pathogenetic Aspects and Serological Diagnostics of Organ
Specific Autoimmune Diseases
7.1: Autoimmune Neurological Diseases
H. J.Willison: Peripheral neuropathies and anti-glycolipid antibodies
R. L. Humbel, G. Foerster, I. Hila, M. Toussaint: Antiganglioside
antibodies a very heterogeneous family of biomarkers
U.Wurster, K. Kollewe, B. Mohammadi, T. Sinzenich, S. Petri: Ganglioside
antibodies in amyotrophic lateral sclerosis
I. Janatkova, K. Malickova, A. Potmesilova, B. Potuznikova, T. Fucikova:
Co-Incidence of serum anti-ganglioside antibodies and microbial infection
in patients with inflammatory peripheral neuropathy
S. Jarius, C. Probst, K. Borowski, D. Franciotta, B.Wildemann,W. Stöcker,
K.-P.Wandinger: Detection of antibodies to aquaporin-4 by indirect
immunofluorescence employing a standardized recombinant target antigen
P.W. Modderman, I. Ketelslegers, R. Q. Hintzen, D. Hamann: Antibodies
against aquaporin-4 in neuromyelitis optica: cell-based assay vs.
immunoprecipitation assay
K.-P.Wandinger, J. Dalmau, K. Borowski, C. Probst, K. Fechner,W. Stöcker:
Recombinant immunofluorescence assay for the detection of anti-glutamate
receptor (type NMDA) antibodies in the differential diagnosis of
autoimmune encephalopathies
J. Fraussen, K. Vrolix, P. Martinez-Martinez, M. Losen, R. Hupperts, A.
Van Diepen, R. Medaer, B. VanWijmeersch, E. Meulemans, M. H. De Baets, P.
Stinissen, V. Somers: Immortalized B cell lines from multiple sclerosis
patients produce antibodies that bind an oligodendrocyte precursor cell
line
C. Govarts, K. Somers, R. Hupperts, P. Jongen, P. Stinissen and V. Somers:
Analysis of autoantibody profiles in cerebrospinal fluid and serum of a
relapsing-remitting MS patient with active disease using Serological
Antigen Selection
J. Svarcová, L. Fialová, A. Bartos, L. Cechova, D. Dolezil, I.M. Malbohan:
Anti-tau antibodies in patients with multiple sclerosis
L. Fialová, J. Svarcová, A. Bartos, I.M. Malbohan: Avidity of antibodies
against tau protein in patients with multiple sclerosis
7.2: Gastrointestinal and Liver Diseases
D. Roggenbuck, G. Hausdorf, L. Martinez-Gamboa, D. Reinhold, T. Büttner,
C. Büning, E. Feist, K. Conrad: The zymogen granule membrane glycoprotein
GP2 is a major autoantigen of pancreatic antibodies – relevance in
diagnostics and pathogenesis of Crohn’s disease
W. Stöcker, B. Teegen, C. Probst, K. Aulinger-Stöcker, D. Ludwig, M.O.
Glocker, L. Komorowski: CUZD1 and GP2 are the exocrine pancreas
autoantigens in Crohn’s disease
L. Komorowski, B. Teegen, C. Probst,W. Schlumberger,W. Stöcker: ELISA for
the detection of autoantibodies against DNA-bound lactoferrin in
ulcerative colitis
D. Bouzid, Y. Ben Haj Hmida, A. Amouri, N. Mahfouth, A. Kammoun, M. Ben
Ayed, H. Makni, N. Tahri, H. Masmoudi: Antineutrophil cytoplasmic
antibodies and HLA II in ulcerative colitis Tunisian patients
D. Villalta, E. Tonutti, C. Prause, S. Koletzko, M. Stern, M.W. Laass, H.
H. Uhlig, H. J. Ellis, P. J. Ciclitira, T. Richter, C. Dähnrich,W.
Schlumberger, T. Mothes: Diagnosis of IgA-deficient coeliac disease by
assay of IgG antibodies against deamidated gliadin (GAF3X)
M. Miler, A. Tesija Kuna, O. Zaja Franulovic, N. Vrkic: Antibodies against
deamidated gliadin as a novel serologic marker for celiac disease
T. Krieger, F. Haag: Deamidated gliadin antibodies facilitate diagnosis in
celiac disease
X.Guo, R. Lerner, L. Sana,W. Kumfert and T. Prestigiacomo: Validation of
Bio-Rad gastrointestinal assays for use on the Evolis™ and Evolis™ twin
plus systems
G. Hausdorf, D. Roggenbuck, E. Feist, T. Büttner, K. Conrad, C. Berg, R.
Klein: Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a
novel ELISA – revival of a disease-activity marker in autoimmune hepatitis
(AIH)
A. Neininger, J. Kaiser, J.Weyand, C. Berg, S. Buck, R. Klein, H.
Haubruck, B. Liedvogel: Use of recombinant autoantigens in profiling of
PBC associated antibodies
7.3: Various Autoimmune Diseases and Cancer
M. Cojocaru, I.M. Cojocaru, I. Silosi, S. Rogoz: Prevalence of ovarian
antibodies in women with unexplained recurrent pregnancy loss
K. Zöphel, P. von Landerberg, D. Roggenbuck, G.Wunderlich, T. Grüning, J.
Kotzerke, K. J. Lackner, B. Rees Smith: TSH receptor antibody (TRAb)
assays using human monoclonal autoantibody M22 are more sensitive than
bovine TSH based assays
V. Kocoski, N. Beyersdorf, A. Schlipp, V. Boivin, T. Kerkau, R. Jahns:
β1-adrenoreceptor autoantibodies in a Lewis rat model of dilated
cardiomyopathy
C. Dähnrich, A. Rosemann, C. Probst, L. Komorowski, W. Schlumberger, W.
Stöcker, A. Recke, C. Rose, D. Zillikens, E. Schmidt: ELISA using
ectodomains of desmoglein 1 and 3 expressed in HEK293 for sensitive and
specific detection of pemphigus autoantibodies
D. Sánchez, A. Pekáriková, L. Palová-Jelínková, T. Mothes, H.
Tlaskalová-Hogenová, L. Tucková: Fine specificity of serum IgA and IgG
autoantibodies against Calreticulin in oncological patients
A. Pekáriková, D. Sánchez, L. Palová-Jelínková, M. Simsová, Z. Benes, I.
Janatková, I. Hoffmanová, P. Drastich, T. Mothes, H. Tlaskalová-Hogenová,
L. Tucková: Occurrence of autoantibodies to calreticulin in oncological
patients and patients from risk groups
Chapter 8: Biological Therapy of Autoimmune Diseases
M. Aringer, J. S. Smolen: Biological therapy of rheumatic diseases
A. Kessel, A. Snir, E. Toubi: The role of B cells in immunoregulation
F. Hiepe, B. F. Hoyer, I. M. Mumtaz, T. Yoshida, A. Radbruch: Targeting of
memory plasma cells as therapeutic option in autoimmune diseases
D. Cornec and P. Youinou: Has B-cell depletion any effects on circulating
autoantibody?
A. Kromminga: Immune reactions induced by therapeutic proteins
P. van Schouwenburg, G.Wolbink, L. Aarden, D.Wouters: Measuring
anti-adalimumab levels in the presence of adalimumab
V. Kocoski, N. Beyersdorf,M.Merkl, D. Schmidt, V. Boivin, T. Kerkau, R.
Jahns: Peptide-based immunotherapy of dilated cardiomyopathy in a Lewis
rat model
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